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KMID : 0370220030470020078
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Yakhak Hoeji
2003 Volume.47 No. 2 p.78 ~ p.84
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Solid Lipid Microspheres for Controlled Release Abdominal Injection of Local Anesthetic
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박용근/Park YK
이종화/김동우/윤재남/전일순/이은미/이계원/지웅길
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Abstract
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Local anesthetics are used to reduce pain, but they are so frequently injected to patients. So, we prepared lidocaine solid lipid microspheres (SLM) as long acting abdominal i njection using spray drying method and evaluated drug entrapment, particle size, SEM, zeta potential and in vitroand in vivo drug release pattern. The particle sizes of SLM were 30~100 μm and it is enough to inject into abdominal tissue. The entrapment efficiency of SLM was over 95% as spray drying method. Sufactant and PC decreased the burst effect by 20~30%. In in vivo test, C-6 showed controlled release concentration profile in plasma for 8 days and C-5 sustained longer than we expected.
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